On Tuesday while he was in his Audi at a junction in Scotland Street, the 26-year-old was targeted at 23:55, said Police.
He died a short time later when He was taken by ambulance to the Queen Elizabeth University Hospital.
Officers were treating his death as murder, said A spokesman for Police Scotland.
Services from the Shields Road Subway are also being affected by the incident.
Police have closed Shields Road between Scotland Street and St Andrews Drive and also closed Scotland Street between Shields Road and Carnoustie Street.