With 95 per cent of the vote counted, Mr Trump is ahead by more than 100,000 votes in Florida.
With the Republicans retaining control of the US House of Representatives, according to media reports, Mr Trump is leading Mrs Clinton by 36 Electoral College votes.
The race was too close to call in Florida, With voting completed in more than two-thirds of the 50 US states, New Hampshire and North Carolina, states that could be vital to deciding which contender wins the presidency.
According to US media, Mrs Clinton is now projected to win Virginia and Colorado while Mr Trump has claimed Ohio.
While Mrs Clinton has 131 Electoral College votes, Mr Trump has won 167 votes.
It takes 270 votes to win, There are 538 Electoral College votes allotted to the 50 states and the District of Columbia.
Mr Trump has claimed 18 states to Mrs Clinton’s 13. Thirty-one states have been called so far.
Both candidates scored early victories in states where they were expected to win.
With Mr Trump needing a virtual sweep of about six toss-up states to win, Mrs Clinton had more options to reach 270.
A Clinton win in either Ohio or Florida would likely slam the door on Mr Trump’s chances.
According to an early reading from the Reuters/Ipsos national election day poll, Some 15 per cent of Americans who cast a ballot on Tuesday said it was their first time voting in a presidential election.
This was up from 9 per cent of voters who said so in 2012.